About our Group
SysBio constitutes an interdisciplinary and international group studying spatiotemporal patterns at different biological scales with a Systems Biology perspective. Our main research line focuses on tissue morphogenesis and pursues to unveil the governing principles underlying tissue development and regeneration. We are also curious regarding synchrony in tissues and organs and collaborate with medical doctors to investigate problems of synchrony in the human heart.
Our main approach involves building mathematical and computational models with different degrees of complexity that we later tune, adjusting to the biological evidences or satisfying parsimony principles, in collaboration with experimental colleagues from all around the world.
In the navigation menu, you will find links to our SysBio (current and previous) projects, our publications, grants and the events that we organize.
In SysBio we are always interested in highly motivated candidates to do a bachelor/master thesis, a PhD or a postdoc in our group. Please, send us an email with your CV to Osvaldo Chara (ochara@iflysib.unlp.edu.ar).
Spatiotemporal control of cell cycle during spinal cord regeneration
Morphogenesis during tissue regeneration
Regenerating tissue in a multi-scale model. Recreated by using Morpheus (Starruß et al., 2014. Bioinformatics. 30(9): 1331-1332).
Mechanical models of tissues in development and regeneration
Simulation of a 2D epithelial tissue using Vertex Model. In this simulation red cells divide at random times and green cells do not divide. Generated with SysVert.
Cell recruitment in the developing fly wing
Simulation of a developing imaginal disc where a cell recruitment mechanism is implemented by using a multi-scale computational model (Muñoz-Nava et al., 2020. Dev Biol. 462(2): 141-151). Simulation generated with Morpheus (Starruß et al., 2014. Bioinformatics. 30(9): 1331-1332).
Restitution of synchrony in the human heart
SysBio 